ACRN - Publications/Abstracts

Last updated 2/23/2006
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Publications

Kamada AK, Szefler SJ, Martin RJ, Boushey HA, Chinchilli, VM, Drazen JM, Fish JE, Israel E, Lazarus SC, Lemanske RF, Asthma Clinical Research Network: Issues in the use of inhaled glucocorticoids. Am J Respir Crit Care Med 153:1739-1748, 1996.

Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. N Engl J Med 335:841-847, 1996.

Martin RJ, Wanger JS, Irwin CG, Bartelson BB, Cherniack RM, and the Asthma Clinical Research Network. Methacholine challenge testing: Safety of low starting FEV₁ . Chest 112:53-56, 1997.

Fish JE, Peters SP, Chambers CV, McGeady SG, Epstein KR, Boushey HA, Cherniack RM, Chinchilli VM, Drazen JM, Fahy JV, Hurd SS, Israel E, Lazarus SC, Lemanske RF, Martin RJ, Mauger EA, Sorkness C, Szefler SJ, Asthma Clinical Research Network. An evaluation of colchicine as an alternative to inhaled corticosteroids in moderate asthma. Am J Resp Crit Care Med 156:1165-1171, 1997.

Irvin CG, Martin RJ, Chinchilli VM, Kunselman SJ, Cherniack RM, Lemanke RF, Jr, Asthma Clinical Research Network. Quality control of peak flow meters for multicenter clinical trials. Am J Resp Crit Care Med 156:396-402, 1997.

Martin RJ, Pak J, Kunselman SJ, Cherniack RM, and Asthma Clinical Research Network. Assessment of the AirWatch lung function monitoring system. J. Allergy Clin. Immunol 103 (3):535-536, 1999.

Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG,  Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Jr, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN, Asthma Clinical Research Network. The effect of polymorphisms of the ₂-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Resp Crit Care Med 162:75-80, 2000.

Lin HM, Chinchilli VM.  A measure of association between two sets of multivariate responses. Journal of Biopharmaceutical Statistics (3) 11:139-154, 2001.

Leone FT, Mauger EA, Peters SP, Chinchilli VM, Fish JE, Boushey HA, Cherniack RM, Drazen JM, Fahy JV, Ford J. Israel E, Lazarus SC, Lemanske RF, Martin RJ, McGeady SJ, Sorkness C, and Szefler SJ, for the National Heart, Lung and Blood Institute's Asthma Clinical Research Network. The utility of peak flow, symptom scores and beta-agonist use as outcome measures in asthma clinical research. Chest 119:1027-1033, 2001.

Fahy JV, Boushey HA, Lazarus SC, Mauger EA, Cherniack RM, Chinchilli VM, Drazen JM, Fish JE, Ford JG, Kraft M, Israel E. Lemanske RF, Martin RM, McLean D. Peters SP, Sorkness C, Szefler SJ, and the Asthma Clinical Research Network. Safety and reproducibility of sputum induction in Asthmatic Subjects in a Multicenter Study.  Am J Respir Crit Care Med 163:1470-1475, 2001.

Lemanske J, Sorkness C, Mauger E, Lazarus S, Boushey H, Fahy J, Drazen J, Chinchilli V, Craig T, Fish J, Ford J, Israel E, Kraft M, Martin R, Nachman S, Peters S, Spahn J, Szefler S, and the Asthma Clinical Research Network. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: A randomized controlled trial. JAMA 285 (20):2594-2603, 2001.

Lazarus S, Boushey H, Fahy J, Chinchilli V, Lemanske R, Sorkness C, Kraft M, Fish J, Peters S, Craig T, Drazen J, Ford J, Israel E, Martin R, Mauger E, Nachman S, Spahn J, Szefler S, and the Asthma Clinical Research Network. Long-acting ß₂-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: A randomized controlled trial. JAMA 285 (20):2583-2593, 2001.

Kephart D, Chinchilli V, Hurd S, Cherniack R, for the Asthma Clinical Research Network.  The Organization of the Asthma Clinical Research Network: A multicenter, multiprotocol clinical trials team.  Control Clin Trials;22(Suppl):119S-125S,  2001.

Chinchilli V, Drazen J, Fish J, Lemanske R, Lazarus S, Martin R, for the Asthma Clinical Research Network.  The clinical trials in the initial five-year award period of the Asthma Clinical Research Network. Control Clin Trials 22(Suppl):126S-134S, 2001.

Curley R, Evans R, Kaylor J, Pogash R, Chinchilli V, for the Asthma Clinical Research Network.  Development and deployment of an internet-based data management system for use by the 
Asthma Clinical Research Network.  Control Clin Trials 22(Suppl):135S-155S, 2001.

Hess H, Curley R, Chinchilli V, Cherniack R, Evans R, for the Asthma Clinical Research Network.  Modem remote support of pulmonary-function testing and quality control systems.  Control Clin Trials 22(Suppl):156S-167S, 2001.

Pogash R, Boehmer S, Forand P, Dyer AM, Kunselman S, for the Asthma Clinical Research Network.  Data management procedures in the Asthma Clinical Research Network.  Control Clin Trials 22(Suppl): 168S-180S, 2001.

Kunselman S, Armstrong T, Britton T, Forand P, for the Asthma Clinical Research Network.  Implementing randomization procedures in the Asthma Clinical Research Network.  Control Clin Trials 22(Suppl): 181S-195S, 2001.

Forand P, Kunselman S, Drazen J, Israel E, Pillari A, Armstrong T, Britton T, for the Asthma Clinical Research Network.  Genetic analysis in the Asthma Clinical Research Network.  Control Clin Trials 22(Suppl): 196S-206S, 2001.

Martin R, Kephart D, Dyer AM, Fahy J, Kraft M, for the Asthma Clinical Research Network.  Quality control within the Asthma Clinical Research Network.  Control Clin Trials 22(Suppl): 207S-221S, 2001.

Sorkness C, Ford J, Lemanske R, for the Asthma Clinical Research Network.  Recruitment strategies in the Asthma Clinical Research Network.  Control Clin Trials 22(Suppl): 222S-235S, 2001.

Janson S, Alioto M, Boushey H, for the Asthma Clinical Research Network.  Attrition and retention of ethnically diverse subjects in a multicenter randomized controlled research trial.  Control Clin Trials 22(Suppl): 236S-243S, 2001.

Mauger E, Mauger D, Fish J, Chinchilli V, Israel E, for the Asthma Clinical Research Network.  Summarizing methacholine challenges in clinical research.  Control Clin Trials 22(Suppl): 244S-251S, 2001.

Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahey JV, Fish JE, Ford J., Kraft M, Kunselman S, Lazarus SC, Lemanske RF Jr, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN for the National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network.  Effect of polymorphisms of the b₂-adrenergic receptor on the response to regular use of albuterol in asthma.  Int Arch Allergy Immunol 124:183-186, 2001.

Szefler S, Martin R, King T, Boushey H, Cherniack R, Chinchilli V, Craig T, Dolovich M, Drazen J, Fagan J, Fahy J, Fish J, Ford J, Israel E, Kiley J, Kraft M, Lazarus S, Lemanske R, Mauger E, Peters S, Sorkness C, for the Asthma Clinical Research Network.  Significant variability in response to inhaled corticosteroids for persistent asthma.  J. Allergy Clin. Immunol 109: 410-418, 2002. 

Martin RJ, Szefler, SJ, Chinchilli VM, Kraft M, Dolovich M, Boushey HA, Cherniack RM, Craig TJ, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kunselman SJ, Lazarus SC, Lemanske RF, Jr, Peters SP, Sorkness CA. Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Resp Crit Care Med 165:1377-1383, 2002.

Israel E, Chinchilli, VM, Ford JG, Boushey HA, Cherniack RM, Craig T, Deykin A, Fagan JK, Fahy, J, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM, for the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network  Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomized, placebo-controlled cross-over trial.  Lancet 364: 1505-1512, 2004.

Deykin A, Lazarus S, Fahy J, Wechsler M, Boushey H, Chinchilli V, Craig T, DiMango E,  Kraft M,  Leone F,  Lemanske R, Martin R, Pesola G, Peters S, Sorkness C, Szefler S, Israel E,  for the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network.  Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol 2005; 115:720-7.

Boushey H, Sorkness C, King T, Sullivan S, Fahy J, Lazarus S, Chinchilli V, Craig T, Dimango E, Deykin A, Fagan J, Fish J, Ford J, Kraft M, Lemanske R, Leone F, Martin R, Mauger E, Pesola G, Peters S, Rollings N, Szefler S, Wechsler M, Israel E, for the National Heart, Lung and Blood Institute's Asthma Clinical Research Network.  Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med 352: 15, 1519-1528, 2005.

Larisa V. Buyantseva, Vernon M. Chinchilli, Mark Tulchinsky, Rebecca Bascom, Richard J. Martin, Alternatives for  Measuring Endogenous Adrenocortical Activity in Asthmatics Treated  with  Inhaled Corticosteroids.  Endocrine Research, 31(4):245–258, (2005)

Whelan G, Blumer J, Martin R, Szefler S for the Asthma Clinical Research Network and the Pediatric Pharmacology Research Unit Network.  Fluticasone propionate plasma concentration and systemic effect: Effect of delivery device and duration of administration. J Allergy Clin Immunol 2005; 525-530.

Wechsler M, Lehman E, Lazarus S, Lemanske R, Boushey H, Deykin A, Fahy J, Sorkness C, Chinchilli V, Craig T, DiMango E, Kraft M, Leone F, Martin R, Peters S, Szefler S, Liu W, Israel E, for the National Heart, Lung and Blood Institute's Asthma Clinical Research Network.  β-adrenergic Receptor Polymorphisms and Response to Salmeterol. Am J Resp Crit Care Med 173:519-526, 2006.

Denlinger LC, Sorkness CA, Chinchilli VM, Lemanske RF for the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research Network. Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network and Childhood Asthma Research and Education Network. J Allergy Clin Immunol  2006.

Richard J. Martin, MD,a Stanley J. Szefler, MD,a Tonya S. King, PhD,b Monica Kraft, MD,a Homer A. Boushey, MD,g Vernon M. Chinchilli, PhD,b Timothy J. Craig, DO,b Emily A. DiMango, MD,e Aaron Deykin, MD,c John V. Fahy, MD,g Elliot Israel, MD,c Stephen C. Lazarus, MD,g Robert F. Lemanske, Jr, MD,d Frank T. Leone, MD,f Gene R. Pesola, MD, MPH,e Stephen P. Peters, MD, PhD,f Christine A. Sorkness, PharmD,d Lisa A. Szwejbka, MSPH,b and Michael E. Wechsler, MD,c for the National Heart, Lung, and Blood Institute’s Asthma Clinical Research Center.  The Predicting Response to Inhaled
Corticosteroid Efficacy (PRICE) trial.  J Allergy  Clin  Immunol Vol. 119, Number 1, January 2007.

Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, Deykin A, DiMango E, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lemanske RF, Leone F, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Wechsler ME, Fahy, JV for the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Smoking Affects Response to Inhaled Corticosteroids or Leukotriene Receptor Antagonists in Asthma.  Am J Respir Crit Care Med Vol 175. pp 783–790, 2007.

Aaron Deykin, MD, Michael E. Wechsler, MD, MMSc, Homer A. Boushey, MD , Vernon
M. Chinchilli, PhD, Susan J. Kunselman, MA, Timothy J. Craig, DO, Emily DiMango, MD,
John V. Fahy, MD, ChB, Monica Kraft, MD, Frank Leone, MD, Stephen C. Lazarus, MD,
Robert F. Lemanske, Jr., MD, Richard J. Martin, MD, Gene R. Pesola, MD, MPH,
Stephen P. Peters, MD, PhD, Christine A. Sorkness, PharmD, Stanley J. Szefler, MD
and Elliot Israel, MD for The National Heart, Lung, And Blood Institute’s Asthma Clinical
Research Network: Combination Therapy with a Long-Acting β-Agonist and a Leukotriene Antagonist in Moderate Asthma.  Am J Respir Crit Care Med Vol 175. pp 228–234, 2007.

Michele L. Shaffer, Vernon M. Chinchilli, Including multiple imputation in a sensitivity analysis
for clinical trials with treatment failures.  Contemporary Clinical Trials 28 (2007) 130–137.

Simon LJ, Chinchilli VM. A Matched Crossover Design for Clinical Trials. Contemporary Clinical Trials 28 (2007) 638–646

Stephen C. Lazarus, Vernon M. Chinchilli, Nancy J. Rollings, Homer A. Boushey, Reuben Cherniack, Timothy J. Craig, Aaron Deykin, Emily DiMango, James E. Fish, Jean G. Ford, Elliot Israel, James Kiley,Monica Kraft, Robert F. Lemanske, Jr., Frank T. Leone, Richard J. Martin, Gene R. Pesola, Stephen P. Peters, Christine A. Sorkness, Stanley J. Szefler, Michael E. Wechsler, and John V. Fahy, for the National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network: Smoking Affects Response to Inhaled Corticosteroids or Leukotriene Receptor Antagonists in Asthma.  Am J Respir Crit Care Med Vol 175. pp 783–790, 2007

Abstracts

Mauger EA, Mauger DT, Chinchilli VM, Asthma Clinical Research Network. PC₂₀ as an endpoint in asthma clinical trials. Biometrics Society Eastern North American Region Meeting. Page 93, March 1997.

Chinchilli VM, Kunselman SJ, Asthma Clinical Research Network. Use of a mixed-effects linear model in an asthma clinical trial. Biometrics Society Eastern North American Region Meeting. Page 138, March 1997.

Lemanske RF, Sorkness CA, Kunselman SJ, Asthma Clinical Research Network. Differences in skin test responses between minority and non-minority patients with mild asthma in a multicenter clinical trial. J Allergy Clin Immunol 99:S128, 1997.

Janson S, Boushey H, Wong H, Au D, Martin R, Pak J, Okikawa J, and the Asthma Clinical Research Network. Improvement in four components of MDI technique immediately and two weeks after instruction and evaluation of contribution of each component to change in FEV₁. Am J Respir Crit Care Med 155(4):A260, 1997.

Janson S, Boushey H, and the Asthma Clinical Research Network. Attrition and retention of ethnically diverse subjects in a multi-center randomized trial. Am J Respir Crit Care Med 155(4):A310, 1997.

Boushey H, Janson S, Wong A, Au D, Martin R, Pak J, Okikawa J, and the Asthma Clinical Research Network. Effects of an automated delivery device on correctness of MDI use over 2 weeks in asthmatic adults. Am J Respir Crit Care Med 155(4):A893, 1997.

Mauger EA, Chinchilli VM. Imputing data for PC₂₀ under a trivariate response model. Biometrics Society Eastern North American Region Meeting. Page 217, March 1999.

Kunselman SJ, Chinchilli VM, Baker DK. The responsibilities and requirements of a data coordinating center in a multicenter, multiple protocol network. Controlled Clinical Trials 20 (2S):  72S, 1999.

Kunselman SJ, Chinchilli VM, Lazarus SC, Lemanske RF, Mauger EA. Design and randomization complexities of the SOCS and SLIC trials of the Asthma Clinical Research Network. Controlled Clinical Trials 20 (2S):  73S, 1999.

Kunselman SJ, Armstrong T, Chinchilli VM, Rawa P, Martin RM.  Establishing a data quality monitoring system for the DICE trial of the Asthma Clinical Research Network.  Controlled Clinical Trials 21 (2S):  121S, 2000.

Chinchilli VM, Mauger EA. The design of clinical trials in the Asthma Clinical Research Network. Joint Statistical Meetings, Pages 326-327, August 2000.

King TS, Chinchilli VM, Asthma Clinical Research Network.  Robust estimators of the concordance correlation coefficient.  Joint Statistical Meetings,  Page 50, August 2001.

Rollings, NJ, Zimmerman, RR, King TS, Sorkness, CA. Medication Event Monitoring System (MEMS®): The Asthma Clinical Research Network (ACRN) Experience. American Academy of Allergy, Asthma & Immunology, Page 223, March 2004.

Kunselman, S, Armstrong, T, Chinchilli, V, Fagan, J, Ford, J, Israel, E. Design and implementation of an asthma clinical trial with exclusions and matching on the basis of genotype. Clinical Trials: Journal of the Society for Clinical Trials, Vol 1, Supplement 1, Page 224, 2004.

Pogash, R, Haak, T, Grella, V, Zimmerman, R, Doty, L. Using the web for securely managing the Asthma Clinical Research Network (ACRN) and the Childhood Asthma Research and Education (CARE) Network. Clinical Trials: Journal of the Society for Clinical Trials, Vol 1, Supplement 1, Page 227, 2004.

Bixler, K, Engle, L, Zimmerman, R. Procedures for Employing a Medication Event Monitoring System (MEMS V) for the Asthma Clinical Research Network.  Clinical Trials: Journal of the Society for Clinical Trials, Vol 1, Supplement 1, Page 234, 2004.

Ferrari, L, Wolff, A.  Certification Application for the Asthma Clinical Research Network (ACRN) and The Childhood Asthma Research and Education (CARE) Network. Clinical Trials: Journal of the Society for Clinical Trials, Vol.2, Supplement 1, Page S47, 2005.

Stempka, C, Whisler S, Pogash, R.  Data Corrections Application for the Asthma Clinical Research Network (ACRN) and The Childhood Asthma Research and Education (CARE) Network. Clinical Trials:   Journal of the Society for Clinical Trials, Vol.2, Supplement 1, Page S47, 2005.

Hilperts, K, Haak, T. Improvements Within Genetics Sample Tracking for the Asthma Clinical Research Network (ACRN). Clinical Trials: Journal of the Society for Clinical Trials, Vol.2, Supplement 1, Page S48, 2005.

Lucier, J, Vignati, A. Standard Forms Used in the Asthma Clinical Research Network (ACRN). Clinical Trials:  Journal of the Society for Clinical Trials, Vol.2, Supplement 1, Page S48, 2005.

Sheaffer, K, Vignati, A. Assigning Protocol Violations in the Asthma Clinical Research Network (ACRN). Clinical Trials: Journal of the Society for Clinical Trials, Vol.2, Supplement 1, Page S49, 2005.

Kunselman, S, Bixler, K, Haak, T, Hilperts, K, Popescu, S. Establishment of a Demographics Registry for the Asthma Clinical Research Network (ACRN). Clinical Trials: Journal of the Society for Clinical Trials, Vol.2, Supplement 1, Page S69, 2005.

Kunselman S,Chinchilli V, Zimmerman R, Israel E, Deykin A. Statistical and Safety Considerations for Stopping an Asthma Study: The ACRN SLiMSIT Trial. Clinical Trials: Journal of the Society for Clinical Trials, Vol.4, Supplement 1, Page 43, 2007.